G11 SUPER GIO
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03
CHALLENGE MISSIONbonding, polarity, geometry, and properties

bonding, polarity, geometry, and properties

INDEPENDENT DEFENSEINDEPENDENT TRANSFER

Design a soluble molecule

A drug must dissolve in blood yet cross a lipid membrane. Candidate A is entirely hydrocarbon; B has one charged group and a large nonpolar ring; C has six permanent charges.

  1. Water favors polar or charged regions.
  2. Membranes favor some nonpolar character.
  3. Design requires a balance and may depend on transporters.

Which candidate is the strongest starting point?

MODELMolecular Geometry Rig
PHYS
PROVEChoose with evidence
CLUE

Pause. Find what matters. Then make your move.